Metabolic Syndrome and its Components among Patients attending MOPD of a Tertiary Care Centre

This was a hospital based study done to see the demographic profile of patients with metabolic syndrome in Bangladesh. A total of 334 patients attending in medicine OPD BSMMU were included in this study. According to modified NCEP ATP III criteria 27.2% of subjects aged ≥ 20 years had the metabolic syndrome and it was more commonly seen in women than in men (32.4% vs 21.7%). The metabolic syndrome increased with age in both sexes (40-49 years age groups 24.2% to 50-59 years age groups 35.2%). The metabolic syndrome was also significantly associated with postmenopausal period, family income, leisure time exercise (60 min/wk), low physical activity, self reported high intake of carbohydrate diet, presence of family history and past history of components of the metabolic syndrome.

Demographic Profile of Patients with Metabolic Syndrome in Bangladeshi Population

This was a hospital based study done to see the demographic profile of patients with metabolic syndrome in Bangladesh. A total of 334 patients attending in medicine OPD BSMMU were included in this study. According to modified NCEP ATP III criteria 27.2% of subjects aged ≥ 20 years had the metabolic syndrome and it was more commonly seen in women than in men (32.4% vs 21.7%). The metabolic syndrome increased with age in both sexes (40-49 years age groups 24.2% to 50-59 years age groups 35.2%). The metabolic syndrome was also significantly associated with postmenopausal period, family income, leisure time exercise (60 min/wk), low physical activity, self reported high intake of carbohydrate diet, presence of family history and past history of components of the metabolic syndrome.

Colonoscopic Findings and Histological Changes in Patients Suffering from Ankylosing Spondylitis with Normal Bowel Habit

Ankylosing Spondylitis is a form of spondyloarthropathies characterized by chronic inflammation of the joints of axial skeleton, manifested clinically by pain and progressive stiffening of spine. It is evidenced that sero-negative spondyloarthropathies are closely related with gut inflammatory lesions. This inflammatory gut lesions may be clinically silent or with abnormal bowel symptoms. This observational study was done with an intension to see the inflammatory gut lesions in ankylosing spondylitis patients having normal bowel habit. In this study thirty eight ankylosing spondylitis patients were selected by New York revised criteria having normal bowel habit. All patients were subjected to full colonoscopy with biopsy. Only 7.89% patient showed macroscopic abnormalities (Grade-1 & 2) and 15.87 % had microscopic non-granulomatous inflammatory lesion of grade1 &2 on biopsy. This study concluded that gut inflammatory lesions in ankylosing spondylitis patients with normal bowel habit is not remarkable. So before making concrete opinion, further large sized comparable study with & without bowel symptoms can be warranted. Download

Comparison of Prevalence of the Metabolic Syndrome by Using Different Defining Criteria.

This was a hospital based study done to see the demographic profile of patients with metabolic syndrome in Bangladesh. A total of 334 patients attending in medicine OPD BSMMU were included in this study. According to modified NCEP ATP III criteria 27.2% of subjects aged ≥ 20 years had the metabolic syndrome and it was more commonly seen in women than in men (32.4% vs 21.7%). The metabolic syndrome increased with age in both sexes (40-49 years age groups 24.2% to 50-59 years age groups 35.2%). The metabolic syndrome was also significantly associated with postmenopausal period, family income, leisure time exercise (60 min/wk), low physical activity, self reported high intake of carbohydrate diet, presence of family history and past history of components of the metabolic syndrome.

Aetiological Pattern of Haemoptysis in a Tertiary Level Hospital in Bangladesh

To identify the causes of haemoptysis and to diagnose the diseases clinically and cost effective laboratory investigations in our situation. Fifty consecutive cases of haemoptysis admitted at Rajshahi Medical College Hospital, Rajshahi during 2000-2001 were prospectively studied .Pulmonary tuberculosis was the commonest found in 19 (38%) cases. Tuberculer bacilli could be isolated in 5 (26.31%) of the cases. Eight (16%) patients were mitral valvular diseases . Bronchial carcinoma was 4(8%) of the series. Three patients (6%) were lung abscess. Six patients (12%) had bronchiectasis. Five patients (10%) had pneumonia. Remaining five (10%) patients were miscellaneous aetiology. In the present series it has been found that pulmonary tuberculosis and mitral valvular disease comprise 54% of the cases. Chest X-ray and sputum examination were found to be the two most useful investigations necessary for aetiological diagnosis of haemoptysis. Within limited resources the aetiological diagnosis of haemoptysis can easily be done in the majority of cases by doing chest X-ray and sputum examination in our country. Download

A Comparison of Lipid Profile Between Sedentary and Non Sedentary Workers

In different epidemiological studies, an association between sedentary life style and incidence of cardiovascular diseases has been demonstrated. Dyslipidaemia is one of the important risk factors of cardiovascular disease. An association of dyslipidaemia with sedentary life style has been considered. This study was carried out among 50 sedentary workers (teachers, office staffs, bank employees) at Pabna District and 50 individuals with non-sedentary jobs matched for age group and sex for the control group to see the association. Body mass index (BMI), blood pressure (BP), plasma level of glucose, total cholesterol, low density lipoprotein (LDL), and triglycerides (Tgs) were found to be significantly higher whereas high density lipoprotein (HDL) was found to be significantly lower among the sedentary workers as compared with the control subjects. Download

The Changes in Levels of Serum Alanine Aminotransferase (ALT) During Anti Tubercular Treatment With 4FDC (Fixed Drug Combination)

Tuberculosis (TB) is emerging as a major public health problem in Bangladesh, which now has the fifth highest burden of TB cases globally. Treatment of TB hampered with poor patient compliance and intolerance at least partly due to the adverse drug reactions, one of which is hepatotoxicity. Serum alanine aminotransferase level is an important indicator of such condition and impacts upon the continuation of anti tubercular treatment. A prospective randomized case study was conducted among 62 patients diagnosed as pulmonary tuberculosis receiving category I anti-TB drug treatment regimen in the DOTS (Direct observation therapy short-course) providing centers at Pabna district under DOTS during the period of July 2004 to July 2006. Category I comprised of four drugs (Rifampicin, Isoniazid, Ethambutol, Pyrazinamide) combination patients treated for initial 2 months, serum alanine aminotransferase levels were estimated at the first and fourth week of the treatment. Serum billirubin, HBsAg, Anti-HCV was also done to exclude some other liver diseases. 14(22.58%) patients were found to have no significant change, 34(54.84%) patients had their levels in the upper limits, 13(20.97%) patients had their levels in-between the upper limit and twice of the upper limit, while only 1(1.6%) patient crossed the level twice the upper limit. Download

Vertical Transmission of Hepatitis B Virus is the most Important Route of Transmission in Asymptomatic Carriers in Bangladesh

To find out the route of the transmission of HBV in asymptomatic carrier and build up awareness against the transmission of HBV. It was a prospective study in the Dept. of Medicine (IPD & OPD) and Transfusion Medicine in Rajshahi Medical College Hospital from June 2005 to July 2007. 300 asymptomatic carriers of HBV were included. HBsAg was detected incidentally during routine screening tests done for blood donation programme, foreign mission and courses abroad. All the HBsAg positive patients were confirmed by doing HBsAg (ELISA) tests after 6 months. All were positive. Among 300 asymptomatic carriers male 270 and female 30. Age between 15 to 35 yrs. HBeAg positive only in 15 patients. ALT above 60 U/L in 17 patients, HBV-DNA (PCR) detectable in 15 patients, coarse liver echotexture in 20 patients, Oesophageal Varix small size in 02 patients. Serum Albumin, PT, AFP all were normal range. Screening of all the family members of the carriers was done. Among the 300 index cases 130 (43.33%) family members most likely mother,father, brother, sister or cousin were HBVmarkers positive. Liver related death was present in 50 families (16.66%). Download

Pulmonary Embolism- A New Challenge In Diagnosis

Pulmonary embolism is one of the dreadful situations demanding immediate interventions. Any delay in instituting treatment would lead to death. We have dearth of idea about the condition, many patients go undiagnosed and underevaluated. Dyspnoea, tachypnoea, hypoxemia are cardinal features of PE. Deep vein thrombosis (DVT) and PE have almost similar risk factors. Among the risk factors recent immobilization, major surgery, recent limb trauma /or surgery, pregnancy post partum etc. Important diagnostic tools like VQ scanning, assay of D-dimer could only be done only at highly specialized centers. If immediate treatment is undertaken many deaths could be averted. An X-ray chest, ECG, echocardiography could give some important diagnostic clues. Download

Biweekly Oxaliplatin in Combination with Continuous Infusional 5- Fluorouracil and Leucovorin (Modified FOLOX-4 Regimen) as First-Line Chemotherapy for Elderly Patients with Advanced Gastric Cancer

Gastric cancer is one of the common carcinomas in human being. The incidence of gastric cancer increases with older age. Current epidemiologic data indicate that gastric cancers are rare in people under 45 years and frequently occur in the 6th and 7th decades. However, Patients older then 65 years have been often excluded from or underrepresented in the trials of new cancer therapies.Randomized trials has a real, although modest effect on survival in patients with advanced gastric cancer (AGC),4 with respect to both median survival and quality of life. While, it is uncertainty that if chemotherapy should be offered to elderly patients. Gastric cancer is considered to be a chemotherapy sensitive disease, but some traditional active single-agents like Mitomycin C,Anthracyclines (Doxorubicin, Epirubicin), Cisplatin, or Etoposide are considered as poorly tolerated or less effective,

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